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4 The role of the endothelial cell glycocalyx in sepsis 4.1 Early damage and the vicious circle of endothelial glycocalyx pathology in sepsis Sepsis is a systemic disease, but the vascular endothelium is the first site that is exposed to bacterial endotoxin

Your choice depends on your specific water quality goals and operational scale

Some users alternate between the affected shoulder area and a systemic site like the abdomen, reasoning that both local and systemic administration provide benefit