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These can occur with the aqueous solution or the crystalloid suspension form, employed to confer them a longer-lasting effect.2,3 Skin hypopigmentation has been reported to occur in 1.3%6% of patients who underwent local corticosteroid injection.2,4 It generally occurs 14 months after injection and takes 630 months to resolve.1 Subcutaneous fat atrophy after local injection of corticosteroids has an estimated incidence that varies from 1.5 to 40%.510 In most cases, these two complications are self limited but may last 6 to 24 months.11 Rare cases have been described where no spontaneous improvement occurs, in which surgical treatment should be considered

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TIAMINAL B12 50,000 - Solucin inyectable Sustancia(s): Lidocana, Tiamina Hcl (vitamina B1), Vitamina B12 (cobalamina, Cianocobalamina, Hidroxocobalamina) Presentaciones: 1 Caja, 1 Frasco(s) mpula, 10 mL, 1 Caja , 5 Frasco(s) mpula , 2 ml FORMA FARMACUTICA Y FORMULACIN: Frasco mpula con 10 mL Cada mL contiene: Cianocobalamina (vitamina B12) 5,000 g Clorhidrato de tiamina (vitamina B1) 100 mg Clorhidrato de lidocana 1 mg Vehculo cbp 1 mL Cada frasco mpula contiene: Cianocobalamina (vitamina B12) 10,000 g Clorhidrato de tiamina (vitamina B1) 200 mg Clorhidrato de lidocana 2 mg Vehculo cbp 2 mL INDICACIONES TERAPUTICAS: TIAMINAL B12 50,000 est indicado en la prevencin y/o tratamiento de la deficiencia por aumento de los requerimientos diarios o por una ingesta deficiente de las vitaminas contenidas en su frmula

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Combination of metabolic inhibitors with immune checkpoint blockade: Pairing PD-1/PD-L1 or CTLA-4 inhibitors with agents targeting cancer cell metabolism (glycolysis, glutaminolysis) to simultaneously reduce metabolic competition and enhance checkpoint inhibitor efficacy

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