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When tumor cells undergo ferroptosis, they release damage-associated molecular patterns (DAMPs) such as high mobility group box 1 (HMGB1), adenosine triphosphate (ATP), and KRASG12D, which engage pattern recognition receptors (e.g., toll-like receptor 4,TLR4

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We thus sought to determine if short-term IF lead to changes in mitochondrial bioenergetics in different tissues

This process constitutes the noncanonical glutamine metabolic pathway, which supports macromolecule synthesis and maintains redox homeostasis [154]