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These findings demonstrate that this class of covalent small-molecule degraderswhile mechanistically distinct from conventional PROTACscan achieve excellent cellular durability with significantly faster kinetics, suggesting favorable drug-like properties

GPX4 suppression alone had no impact on the relative abundance of Foxp3 + regulatory CD4 + T cell (Tregs) or MDSC populations, but significantly affected these cell frequencies in the context of immunotherapy (Fig

Pathogens 12(7):874 Ansari F, Lee CC, Rashidimehr A, Eskandari S, Ashaolu TJ, Mirzakhani E, Pourjafar H, Jafari SM (2024) The role of probiotics in improving food safety: inactivation of pathogens and biological toxins