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Indomethacin, a non-steroidal anti-inflammatory drug, develops gastropathy by inducing reactive oxygen species-mediated mitochondrial pathology and associated apoptosis in gastric mucosa: a novel role of mitochondrial aconitase oxidation

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Furthermore, lactate can be metabolically coupled to histone modifications: excess lactate inside the cell can be converted to lactyl-CoA, which non-enzymatically acylates histone lysines to form histone lactylation marks (such as H3K18-lactyl) 40

A foul odour is a strong indicator of spoilage, bacterial growth, mold, or chemical breakdown, and the product should be avoided to prevent adverse effects