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Dynamic cycling of membrane phospholipids Glycerophosphocholine (GPC), phosphocholine (PC), and (to a lesser extent) free choline are the primary sources of the tCho signal [13]

Patients may reject drug therapy due to disbelief of the diagnosis, negative beliefs about treatment efficacy, fear of potential side-effects, mistrust of modern medicine or beliefs in self- or alternative treatment

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RA-FLSs have tumor cell-like anti-apoptotic characteristics, and inhibition of their proliferation and migration has been the focus of attention in RA therapy