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Antioxidant and associated enzymes

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Copper ions additionally stimulate lysyl oxidase, the enzyme responsible for cross-linking collagen and elastin in the extracellular matrix surrounding follicles

This key effect of GSHee is connected to the findings that GSHee reduced the ability of fentanyl to lower pH, pO 2 and sO 2 while elevating pCO 2 (all consistent with a fall in Ve) and blunted the fentanyl-induced increase A-a-gradient (i.e., impaired gas-exchange in the lungs)