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If increasing retatrutide from 2 mg to 4 mg, hold cagrilintide at its current dose

1 At the same time, our own prior in vitro studies at the mouse mu-opioid receptor (mMOR) had shown that mitragynine acts as either a competitive antagonist or a partial agonist depending on the assay system used, calling into question the ability of this compound to have a direct agonist effect on MOR in rodents and consistent with a metabolite-driven analgesic effect