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Cell 34 , 267282 (2015)

They used AlphaFold2 to predict the structure of the original sensor, removed the unstructured linker computationally, and reoriented Grx1 to align the GSSG binding site with the reactive cysteines of roGFP2

B Vitamins: Various B vitamins have been shown to play a critical role in mitochondria function, such as biotin and vitamin B-12

Notably, ALOX5 also plays a critical role by producing pro-ferroptotic 5-HpETE-PE, which amplifies inflammation and ischemiareperfusion injury (Aparoy et al