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The peptide has been studied for its potential influence on enzymes and proteins associated with circadian rhythm, suggesting a possible connection to the regulation of sleep-related hormonal cycles

Arsic B, Dimitrijevic D, Kostic D

Among surviving patients, the most severely affected patients have intellectual disability, with IQs ranging from the low 50s to around 60, progressive cerebellar disease and ataxia, recurrent bacterial infections, chronic metabolic acidosis, and hemolytic anemia

5-Hydroxytryptophan, the precursor to serotonin, is an ideal supplement for low serotonin levels in DS given its low rate of adverse effects compared with selective serotonin reuptake inhibitors