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Improvements were also noted in SCCAI score and TNF- although no significant differences were observed in body weight, BMI, waist circumferences, or blood pressure between the intervention and control groups

It is also used to treat a range of conditions such as dystonia, excessive sweating, an overactive bladder, and is used cosmetically

Option (Evidence Strength: Grade C) One randomized trial with an oral PPS group for comparison reported that CyA (3 mg/ kg/day divided into two doses) resulted in 75% of patients experiencing clinically significant improvement compared to 19% of a PPS comparison group after six months of treatment

Noppert GA, Aiello AE, ORand AM, Cohen HJ