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Name: walter klower Wolter Kluwer / UpToDate – European Medical Association Wolters Kluwer ELM Solutions -
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Researchers achieved attenuation by knocking out the msbB and purI genes and introduced a human IL-2 expression cassette, aiming to achieve tumor-selective colonization and local immune activation while minimizing systemic toxicity

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Otherwise the recurrent thawing and freezing process could compromise the products integrity

By taking the negative logarithm of the p -values from the enrichment analysis and filtering for pathways significantly enriched in both the transcriptomic and proteomic data, key pathways such as protein digestion and absorption and the PI3K-Akt signaling pathway were identified