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In addition, elevated level of cortisol, vascular endothelial growth factor (VEGF), indicative of a weakened blood brain barrier, as well as decreased level of acetylcholine has been reported

458 Treatment with eNAMPT can increase the expression of lipoprotein lipase and PPAR in preadipocytes and promote the expression of fatty acid synthase in differentiated adipocytes, which indicates that eNAMPT may be a positive regulator in adipocytes lipid metabolism