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Moreover, it has been recently summarized that, like apoptosis and necroptosis in nucleated cells [26], eryptosis and erythronecroptosis are mutually exclusive [28]

Depending on the conditions, ~0.1%0.4% of glycolytic intermediates can be converted to the side-product methylglyoxal, which belongs to -dicarbonyl compoundsone of the most reactive RCS ( Figure 2 The polyol pathway is another important contributor to RCS and AGE pool, that becomes activated under hyperglycemic conditions

It plays a critical role in modulating AH outflow, cell adhesion, actomyosin contraction, and cellular rigidity (27)

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