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Consequently, there is an increase in intestinal permeability and translocation of intestinal flora, leading to the release of enterogenic endotoxins into the bloodstream which act on the original organ via the circulatory system, further exacerbating deterioration of the intestinal organ

GLP-1 RA users vs non-users more commonly had T2DM, enrolled at an endocrinology site, greater BMI (p 60 years old had a greater risk of all-cause mortality vs those without these risk factors, and those with HTN were at a greater risk of progression to decompensation