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Because GSH rapidly oxidizes outside cells, variables like collection time, processing delays, temperature, and anticoagulants significantly affect accurate measurement, particularly in the unstable reduced fraction of GSH [118]

Additionally, the review highlights the utility of PLGA nanoparticles in delivering phytochemicals with neuroprotective effects such as polyphenols, flavonoids, and coumarins to overcome challenges associated with their solubility and stability and ultimately enhance their activities for managing PD

For example, in CRC and hepatocellular cancer, TFR can be targeted by miRNAs including miR-22, miR-31, miR-141, miR-145, miR-152, miR-182, miR-200a, miR-320, miR-758, and miR1946365, resulting in a disruption between TF and TFR and the following iron importing process (Zhang et al., 2020e)

So it was a selection pressure genetically to determine who would survive and who would not