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I discuss this in my video The Best Type of Vitamin B12: Cyanocobalamin or Methylcobalamin

Accessory criteria for ALPS were subdivided into primary (abnormal lymphocyte apoptosis assay and presence of pathogenic mutations in genes of the FAS pathway) and secondary criteria, which included characteristic histopathology, the combined presence of autoimmune cytopenia, polyclonal hypergamma-globulinemia, an ALPS-compatible family history, and the presence of elevated biomarkers, such as interleukin-10, interleukin-18, soluble FAS ligand, and vitamin B 12 (Oliveira et al., 2010)

Moreover, increased expression of FAk and paxillin was observed, and it was speculated that these proteins might be involved in mediating the recovery of injured tendons [8]

However, individuals who avoid a variety of foods or have digestive absorption issues may need Vitamin B12 injections to maintain optimal health