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Resveratrol, a polyphenol in grapes and red wine, was shown to reduce body weight gain in high-fat-fed rodents and restore rhythmic oscillation of leptin and insulin, essentially re-synchronizing metabolic hormones that had lost clear rhythms due to diet-induced obesity

Its high selectivity and confirmed membrane permeability make it one of the most reliable small-molecule tools currently available for interrogating the NNMT pathway in both cell-based and in vivo experimental models

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Estimation of extracellular and intracellular ligninolytic activity for the test isolate The dye was incubated with either the culture supernatant or crude cell lysate of the isolate that exhibited the highest activity in the previous assay to assess extracellular and intracellular activity, respectively