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Its one of the most frequent questions we get from the research community, and it's a completely valid one

Discontinuation of SUBLOCADE Treatment: Due to the long-acting nature of SUBLOCADE, if treatment is discontinued, monitor patients for several months for withdrawal and treat appropriately

Implications for Signaling by NE Neurons In light of increasing reports of release of multiple neurotransmitters from the same neuron [19], it is possible that LC neurons are capable of packaging glutamate into vesicles for subsequent release