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Lysosomal dysfunction might play an important role in the development of various diseases, including tumors 14,15,16 , neurodegenerative diseases 17,18,19 , inflammatory diseases 20,21,22 , and cardiovascular diseases 23,24,25 (Table 1)

The metabolic flexibility of melanoma cells enabled them to adapt to therapeutic pressure by rerouting their metabolism through alternative pathways, which limits the effectiveness of therapies targeting a single metabolic pathway

doi:10.1038/nrn920

The clinical clue is the combination of bruising, gum changes, perifollicular bleeding, poor wound healing, joint & muscle pain, and poor diet