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Why the n-terminal acetylation and C-terminal amidation

Imaging studies have demonstrated that chronic cocaine users often exhibit brain atrophy and reduced gray and white matter volumes, particularly in the limbic regions essential for emotional processing and reward (Rando et al., 2013)

The D-amino acid substitution preserves the spatial orientation of amino acid side chains needed for competitive binding to the FOXO4-p53 interaction surface, maintaining biological activity despite the non-natural backbone (PMID: 28340339)

GHK has also been shown to improve wound healing in controlled experiments using animals, such as rats, dogs, and rabbits [8,9,10]