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The clinical and laboratory characteristics of the study participants are shown in Table 1

Of note, consistent with post-translational mTOR inhibition by rapamycin, MYC was significantly upregulated, yet MYC targets were significantly downregulated (Fig

However, the total synthesis of natural products with multiply chiral centers has always been a difficult problem, therefore, simplification and extraction of effective structures of natural inhibitors may be an efficient means to synthetize new type IKK inhibitors in the future

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