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These data raise the possibility that CAR T cells may execute antitumor activity through 2 complementary mechanisms, (a) immediate killing of malignant cells via the release of cytotoxic factors following engagement of CD19 and (b) initiation of a local immune response, which amplifies and sustains the antitumor activity, leading to complete tumor resolution in a subset of patients

Most of the current knowledge on efferotabolism has been derived from studies in atherosclerosis, where defective apoptotic cell clearance contributes to chronic inflammation and plaque progression

Role of ginsenoside Rg1 as a PPAR- activator in protecting against manganese-induced hepatotoxicity: insights into the TLR4/MyD88/MAPK signaling pathway

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