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However, unclear chemical components, unverified functional targets and ambiguous molecular mechanisms have hindered the widespread use of TCMP worldwide [5]

Identification of candidate mutants that respond to APR246 Fastq sequencing reads were trimmed and mapped to TP53 mRNA sequence (NM_000546) using BWA MEM, and resulting BAM files were processed using GATK AnalyzeSaturationMutagenesis to generate read counts for each codon variant

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These medications do not cure the disorder, but rather improve safety and prevent withdrawal symptoms which can lead to relapse or continued drug use