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FIGURE 10 Oxidative stress, associated with high dose MTX, triggers a systemic inflammatory response where proinflammatory cytokines further contribute to tissue damage (Vanessa Legry et al., 2022), ovariectomized mice (Morsy et al., 2022)

At body temperature, a temperature that is far below the melting point of the CoQ10 crystals, the lumpy crystals and plate-like crystals will yield many fewer single CoQ10 molecules than the needle-shaped crystals will