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In the ischemic phase, CBF is reduced, resulting in a deficient supply of glucose and oxygen (Sandoval and Witt, 2008)

Anyway, pro-apoptotic effects were observed in HL60 cells incubated with HOTYR even in conditions not supporting H2O2 accumulation (between 23.8 and 38.0% depending on the media) suggesting that other mechanisms, in addition to the H2O2-releasing activity, could be involved in the pro-apoptotic activity (80)