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if the outer annulus fibrosus subsequently ruptures, the nucleus pulposus completely extrudes (non-contained herniation), potentially protruding into the spinal canal or lateral recess, compressing the cauda equina and nerve roots, causing pain or motor dysfunction (Figure 1)

Following GF-MKD intervention, plasma levels of L-leucine and coumarin decreased by approximately 46% and 60%, respectively, while betaine levels showed a modest increase

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However, to date, strict glycemic control is the only choice to ameliorate diabetes-related cognitive decline, which emphasizes the necessity of identifying draggable molecular targets