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Nevertheless, 14 samples declared as containing only AAS and other substances contained undeclared PCT medicines, including tamoxifen (n = 5), clomiphene (n = 5), raloxifene (n = 3), and exemestane (n = 1) (Table 2)

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Although preclinical studies have illustrated that pure nanotherapeutics possess some therapeutic functions, challenges still remain in their low accumulation at the targeted areas and easy leakage, which may cause therapeutic inefficiency to hinder subsequent clinical translation 23,24,25

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