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Shen et al., 2010)

Some of these features are due to chronic hypoxemia (oxygen deficiency in the blood), and are not specific for IPF, they can occur in other pulmonary disorders

The abnormal DNA methylation mechanisms in related genes, such as polymerase gamma ( POLG ), Matrix metalloproteinase-9 ( MMP-9 ), Peroxisome Proliferator-activated Receptor ( PPAR ), and Ras related C3 botulinum toxin substrate 1 ( Rac1 ), elucidated this process