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Human medical use remains uncertain because BPC-157 lacks FDA approval, standardized dosing, and strong controlled clinical evidence

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found patterning signals like Shh expression were downregulated over time while expression of synthetic genes like TGF- and insulin growth factor (IGF) were upregulated in the same developmental window, providing insights into gene families required for patterning, ECM synthesis, and maintenance of the NP

Similarly, Plavec and Berlec explored the potential of genetically engineered LAB as delivery systems for therapeutic proteins and peptides (Fig