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Absorption of B12 is complex, requiring intrinsic factora glycoprotein secreted by gastric parietal cellsto facilitate uptake in the terminal ileum

In a subsequent mechanistic study, they found that MET first activated the MAPK signaling pathway, followed by the activation of the downstream NF-B-mediated p65 transcription factor, which interacted with the proximal region of the PD-L1 promoter to promote PD-L1 expression [133]

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90-95% (thats a lot) is lost in digestion & flushed out of our system (rendering it relatively pointless) by the kidneys