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Though there are few studies showing a direct correlation, luteolins capacity to alter MAPK signaling pathways offers a strong justification for its application in pulmonary fibrosis treatment

For example, non-small cell lung cancer (NSCLC) patients with higher TNFRSF10B/DR5 expression showed higher response rate to gemcitabine and cisplatin-based chemotherapy [41]

J Clin Invest 127:843856

Creatine supplementation may modestly increase serum creatinine levels, which reflects increased creatine metabolism rather than impaired kidney function