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10.1177/0271678x17713105 53 FrakeR

STAT3 a key oncogene with dual functions of signal transduction and transcriptional activation, which is hyperactivated in the formation of most human cancers and plays a critical role in cell proliferation, angiogenesis, metastasis, and immunosuppression (Ouyang et al., 2022)

Aspartame impaired placenta growth, induced ROS levels, hyper-activated Akt, and downregulated manganese superoxide dismutase (MnSOD) expression (see also Section 4.2.5)

Recent studies have also identified NP-011, a truncated variant of milk fat globule-EGF factor 8, which significantly reduces TGF-1-induced fibrogenesis and collagen accumulation by specifically inhibiting ERK signaling [46]