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These contrasting findings suggest that the endothelium is variably involved and VEGF is not uniquely implicated in the mechanism of endothelial apoptosis in COPD patients

also found that the occurrence of cuproptosis was significantly related to mitochondrial metabolism, providing a more plausible mechanism for explaining the anti-cancer effect of ES depending on the transport of extracellular copper ions and the mitochondrial respiration intensity of cancer cells ( The metabolic selectivity of elesclomol may provide a reference for the treatment of specific metabolic-type tumors as a targeted therapy (210)