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In SOD1 mouse models, end-stage disease is associated with higher markers of M1 activation (such as NOX2 and other reactive oxidative species) compared with higher levels of M2 activation (such as CD163 and brain-derived neurotrophic factor (BDNF)) at disease onset [242]

96 178 The chronic overproduction of endogenous ethanol and its metabolites not only induces hepatic metabolic dysregulation and the development of liver disease, but may also exacerbate neurodegenerative diseases through brain inflammation

Abstract -Conglycinin (-CG), an anti-nutritional factor, is a major allergen in soybeans to induce intestinal dysfunction and diarrhea in neonatal animals, including piglets and human infants