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For tissue extracts obtained from experiments on Langendorff hearts, the peak shapes and separation were affected by interfering contaminants, so to overcome this we modified the HPLC gradient as described in the Supplementary Table 4, keeping the rest of the parameters unchanged

By leveraging the acid-neutralizing nature of the LDH structure, Se/LDH@PEG-M achieves the pH-responsive sustained release of Mito-TEMPO specifically triggered by the acidic OA microenvironment

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Compliance and Consistency: To achieve the desired effects, it is important to maintain consistency in TB-500 nasal spray administration