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Mechanism of TNF- modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression

It is present at millimolar concentrations intracellularly and performs a foundational role in thiol-based redox signaling, protein function, gene expression, cell differentiation, and cell proliferation

Glossary ACC Acetyl CoA Carboxylase AchE Acetylcholinesterase ADH Alcohol Dehydrogenase ALB Albumin ALD Alcohol-related Liver Disease ALT Alanine Aminotransferase AMPK AMP-Activated Protein Kinase APAP Acetaminophen (Paracetamol) AST Aspartate Aminotransferase ATP Adenosine Triphosphate Bax Bcl-2Associated X protein Bcl-2 B-Cell Lymphoma 2 BIP Binding Immunoglobulin Protein CAT Catalase CYP Cytochrome P450 CYP-2E1 Cytochrome P450 Family 2 Subfamily E Member 1 CCNE1 Cyclin E1 COX4 Cytochrome c Oxidase Subunit IV CPT-1 Carnitine Palmitoyl Transferase-1 dpf Days Post Fertilization DsRed Discosoma Red Fluorescent Protein DILI Drug-Induced Liver Injury DRP1 Dynamin-Related Protein 1 EGFP Enhanced Green Fluorescent Protein ER Endoplasmic Reticulum FAS Fatty Acid Synthase FAO Fatty Acid Oxidation GSH Glutathione GSH-Px Glutathione Peroxidase GSR Glutathione Reductase GST Glutathione-S-Transferase -GT Gamma-Glutamyl Transferase HCD High-Cholesterol Diet HCF High-Cholesterol + High-Fructose Diet HFD High-Fat Diet HFrD High-Fructose Diet HO-1 Heme Oxygenase-1 HMGCR 3-Hydroxy-3-Methylglutaryl-CoA Reductase hpf Hours Post Fertilization IFN- Interferon- IL-1 Interleukin-1 Beta IL-6 Interleukin-6 IL-10 Interleukin-10 INH Isoniazid IAA Iodoacetamide LDL-C Low Density Lipoprotein Cholesterol LC3-II Microtubule Associated Protein 1A/1B-Light Chain 3 II LC 50 Lethal Concentration 50% MASLD Metabolic dysfunction-associated steatotic liver disease MAPK Mitogen Activated Protein Kinase MDA Malondialdehyde MFN2 Mitofusin 2 MPO Myeloperoxidase MRP2/4 Multidrug Resistance-Associated Protein 2/4 NAFLD Non Alcoholic Fatty Liver Disease NASH Non Alcoholic Steatohepatitis NADP/NADPH Nicotinamide Adenine Dinucleotide Phosphate NF-B Nuclear Factor Kappa-B NO Nitric Oxide NQO1 NAD(P)H Quinone Oxidoreductase-1 NRF1 Nuclear Respiratory Factor 1 Nrf2 Nuclear Factor Erythroid 2-Related Factor 2 OF Overfeeding PPAR Peroxisome Proliferator-Activated Receptor PI3K Phosphoinositide 3-Kinase PINK1 PTEN-Induced Putative Kinase 1 ROS Reactive Oxygen Species RXR Retinoid X Receptor SOD Superoxide Dismutase STAT3 Signal Transducer and Activator of Transcription 3 TC Total Cholesterol TG Triglycerides TAA Thioacetamide TBil Total Bilirubin T-AOC Total Antioxidant Capacity TNF- Tumor Necrosis Factor Alpha UCP2 Uncoupling Protein-2 UPR Unfolded Protein Response References 1 Abu-SiniyehA.KhataibehM.Al-ZyoudW.Al HoliM