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doi: 10.11477/mf.1416200945 [DOI] [PubMed] [Google Scholar] 46

They are generally more pronounced and longer-lasting than those seen with short-acting peptides due to its prolonged half-life

While the mechanism of such resistance to hepatotoxicity from acetaminophen overdose was not fully elucidated in these patients, autoprotection through upregulation of efflux transporters might be responsible for the development of tolerance to chronic and lethal doses of this drug