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Amino acid metabolism in immune cells: essential regulators of the effector functions, and promising opportunities to enhance cancer immunotherapy

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313,314,315 Moreover, the release of tumor-specific antigens triggers specific immune responses against the tumor itself, resulting in a reduction of distant metastatic lesions known as the abscopal effect

More recently, a family of potent and highly selective mechanism-based suicide substrate inhibitors were developed and shown to promote the irreversible inhibition of gut microbiotadependent generation of TMA, suppression of host TMAO levels, and, in parallel, inhibition of platelet hyperresponsiveness and thrombosis potential in animal models (22)