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Third, although we performed statistical adjustments, the bias of these background factors could not necessarily be eliminated

For non-hematological AEs using multivariate logistic regression analysis, the C/T genotype group of MTHFR_a , high serum RBP level before pemetrexed treatment, high serum B12 level before premedication, and high red blood cell (RBC) count before pemetrexed treatment (Supplementary Table S3(a)) were the crude low-risk factors for G2G4 non-hematological AEs in the first cycle

Kemp SF (2009) Insulin-like growth factor-I deficiency in children with growth hormone insensitivity: current and future treatment options

Nevertheless, they are limited to detecting known resistance gene targets, cannot confirm the actual phenotypic expression of resistance, and are even less capable of identifying unknown or newly emerging resistance mechanisms [14, 15]