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Peer review Peer review information Nature Communications thanks Johannes Huppa, Christian Klein and the other anonymous reviewer(s) for their contribution to the peer review of this work

Along with oxidative stress, these abnormal molecular changes lead to impaired mitochondrial respiratory function, ATP depletion, and various destructive cellular processes, such as mitochondrial fission, mitophagy, and programmed cell death, as we discuss below

Growth hormone secretagogues stimulate the hypothalamic-pituitary-somatotropic axis to increase endogenous GH pulsatility, affecting lean muscle mass and IGF-1 levels