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10.1016/S0006-2952(03)00504-5 31 RallT

In another study, two-month-old mouse tail tendons treated with ribose demonstrated increased hydration levels and decreased transverse stiffness (Andriotis et al ., 2019)

We hypothesize that (i) the slow inhibition observed in the biochemical assay with the recombinant protein with some of the compounds is due to their preferential binding to a slowly populated conformer of the NADP + -TGR(H) complex and (ii) this conformer is already populated in the worm cell interior accounting for the more rapid inhibition of TGR observed in ex vivo worms with the slow inhibitors