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Krishna MC et al (1998) Studies of structure-activity relationship of nitroxide free radicals and their precursors as modifiers against oxidative damage

NAC, however, diminished these effects ( in vivo administration in a smoke-exposed rat model of emphysema prevented increases in lung iNOS expression, 3-nitrotyrosine formation, NF-B activation, and alveolar destruction (Rushworth and Megson, 2014)

Understanding these molecular pathways is key to developing future therapies that could slowor preventvision-threatening scarring