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In a rabbit model of osteoarthritis, intra-articular injection of AOD-9604 combined with hyaluronic acid (HA) demonstrated improvements in cartilage morphology and joint surface integrity

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In addition to the disease process being associated with a breach in the intestinal barrier functions, patients with hematologic and oncologic diseases are particularly at high risks for the development of increased intestinal permeability, due to the frequent use of broad-spectrum antibiotics and chemoradiation

10.1016/j.fitote.2010.06.011 [DOI] [PubMed] [Google Scholar] 11.Wiese S, Esatbeyoglu T, Winterhalter P, Kruse HP, Winkler S, Bub A, et al