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Indeed, in vivo human and rodent studies demonstrated that treatment with the DA precursor L-DOPA causes hyperglycemia due to decreased GSIS 11,12,13,14

By contrast, HR /HER2 + primary tumours have the lowest probability of subtype switching, probably owing to their strong neurotropic properties, 78 since HER2 + phenotype itself is reported to retain high brain-metastasis tendency