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Zhao G et al

Future efforts should employ longitudinal studies to definitively establish the causal relationship between respiratory and neurological diseases, delve deeper into key mediators related to inflammatory factors and oxidative stress, and explore interventions targeting these pathways

These usually lessen over time

Recent studies have demonstrated that in DM muscle fibers, endothelial cells prominently express HIF-1 and HIF-1, while the muscle fibers themselves exhibit expression of HIF-2, as well as VEGF, and VEGF receptors (185)