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While vitamins exhibit potential in the biological mechanisms and treatment strategies for LLD (Figure 1), concerns regarding species differences, dose-dependent effects, and potential toxicity risks must be addressed

In metabolic and nutritional regulation, the GH/IGF-1 system responds dynamically to nutrient status and metabolic signals

550 In Phase II trials (KARDIA-1), zilebesiran reduced systolic blood pressure in all treated patients, with effects lasting 6 months, opening new possibilities for NADs use in treating hypertension and CVDs

In general, replications of the PD-microbiome instances are often poorly developed, presumably as a result of confounding by usage of medication, geographical differences, sequencing methods, and analytical pipelines