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Conclusions Artemisinin and its derivatives exhibit more potent antimalarial activity than iron chelators, likely stemming from their ability to accumulate in the parasites digestive vacuoles, interact more effectively with heme and iron, and thereby disrupt heme/iron homeostasis and utilization

Children naturally have higher numbers of lymphocytes because they develop immunity and actively respond to infection

(Xing, Chun, Qiang, Xiong, & Rui-Hai, 2021) had elucidated the mechanism of the metabolite quercetin-3- O -glucronide and its inhibitory potential by exhibiting reversible and mixed mode of inhibition through the formation of complexes between quercetin and alpha-glucosidase catalyzed by hydrogen bonding and van der Waals forces that Favors enzyme microenvironment

Addition of human albumin potentiated the cytotoxicity of all clinical strains following a prolonged infection (Fig