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Disease-specific propagation patterns Notably, multiple studies using patient brain homogenates have demonstrated distinct -synuclein propagation properties among synucleinopathies, including PD, DLB, and MSA

Section 3(f) of Executive Order 12866 defines a significant regulatory action as any regulatory action that is likely to result in a rule that may: (1) have an annual effect on the economy of $100 million or more or adversely affect in a material way the economy, a sector of the economy, productivity, competition, jobs, the environment, public health or safety, or State, local, or tribal governments or communities

[11] Antimicrobial Effects