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Luo JL, Hammarqvist F, Andersson K

Klerks, M.M., van Bruggen, A.H.C., Zijlstra, C

These mechanisms have been substantiated in animal model studies

In patients already taking 120mg of oral furosemide per day, the nephron must be blockaded at other levels through the addition of a second diuretic (HCTZ, ACZ, or MRA)